Enclave Essentials

The N3C Data Enclave is a secure platform through which harmonized clinical data provided by our contributing members are stored. The Enclave includes demographic and clinical characteristics of patients who have been tested for or diagnosed with COVID-19, and further information about the strategies and outcomes of treatments for those suspected or confirmed to have the virus. Additional data from individuals infected with pathogens such as SARS 1, MERS, and H1N1 are also included to support comparative studies. For more information on the inclusion and exclusion criteria, see the N3C Phenotype. To view a full list of data elements, click here. Data are updated from contributing sites at an average interval of twice a week.

Three tiers of access are available for users depending on the scope and nature of their research; however, all will require verification and approval by the Data Access Committee (DAC) before data can be accessed. Data can be accessed only within the N3C Data Enclave and cannot be downloaded or removed. The three tiers of access are listed on the Data Partnership and Governance Workstream Page. You can also learn more about the levels of data access on the N3C Data Overview page of the NCATS website.

Returning Users

N3C Data Enclave access requires two-factor authentication. After logging in with your institutional credentials, a prompt will appear to enter a 1-time code from the authenticator app previously downloaded during the registration process. (ex. DUO, Free OTP, Google Authenticator, or Microsoft Authenticator).

Log In Here

New Users

N3C invites you to begin your journey within the Enclave and join the collaborative efforts of our partners to better understand and address the most pressing COVID-19 clinical questions.

Create An Account

Domain Teams

N3C Domain Teams enable researchers with shared clinical questions surrounding COVID-19 to collectively analyze data within the N3C Data Enclave and collaborate more efficiently in a team science environment.


See a list of N3C projects that have been submitted through the Data Use Request (DUR) process and approved by the Data Access Committee (DAC).


Explore frequently asked questions specifically related to the access and flow of data in the N3C Data Enclave.


If you have any questions, problems, or concerns, please visit the N3C Support Desk to see available support options.


N3C offers several options to learn about the Enclave and the resources it provides. Watch tutorials, register for course, and more.


Learn about the tools included within the N3C Data Enclave. A searchable tool registry will be available soon!